Other brands include Lovenox and Fragmin. – Adjust dose by 2000 to 4000 units per day – Target anti-Xa 0.35-0.7u/ml • Therapeutic LMWH anti -Xa monitoring is optional for VTE – Periodic anti-Xa monitoring every 4 weeks , or – Adjust LMWH dose according to weight gain, or – No LMHW dose adjustment is also an option Emerging data have suggested that the standard prophylactic doses for the general population (enoxaparin 40 mg/day or dalteparin 5,000 IU/day) are insufficient for anticoagulation during pregnancy. Pregnant women and women of child-bearing potential should be apprised of the potential hazard to the foetus and the mother if enoxaparin is administered during pregnancy. I am taking low dose aspirin daily for this reason as a preventative as I had two losses leading up to getting this sticky bub. I was told today that I was going to have to Inject Clexane from now till 6 weeks after birth. Dosage* LMWH (enoxaparin[Lovenox]) 1 mg per kg subcutaneously every12 hours12. In fertility treatment, Clexane is sometimes prescribed after recurrent miscarriage and implantation failure. ¶ Our "intermediate" dose level differs from that used in society guidelines (eg, ACCP, ACOG). Enoxaparin is renally excreted and specific advice should be sought if the woman has renal impairment. Antenatal and postnatal prophylactic dose of LMWH Weight < 50 kg = 20 mg enoxaparin/2500 units dalteparin/3500 units tinzaparin daily Weight 50–90 kg = 40 mg enoxaparin/5000 units dalteparin/4500 units tinzaparin daily Weight 91–130 kg = 60 mg enoxaparin/7500 units dalteparin/7000 units tinzaparin daily Weight 131–170 kg = 80 mg enoxaparin/10 50%, 75% or full treatment dose) (see Appendix IV) antenatally and for 6 weeks postpartum or until returned to oral anticoagulant therapy after delivery. Hello all, I am 16 weeks pregnant with my first. UFH. Clexane is to help prevent blood clots so that blood can get to bub through the placenta. For pregnant patients hospitalized for severe COVID-19, prophylactic dose anticoagulation is recommended unless contraindicated (see below) (BIII). The jury is out about the optimal dose, though. Some clinicians prefer to use a different "intermediate" dose level such as enoxaparin 40 mg SC every 12 hours; however, this entails a significant increase in the number of injections over the course of the pregnancy. [New 2015] [New 2015] Pregnant women with APS and prior VTE or arterial thromboses should be managed in collaboration with a haematologist and/or rheumatologist with expertise in this area. Maternal side effects are uncommon and include mild localized allergic reactions in 2% and increased bleeding in 2%, which is dose dependent. The use of enoxaparin for thromboprophylaxis in pregnant women with mechanical prosthetic … Enoxaparin does not cross the placenta and is safe for the fetus. Heparin-induced thrombocytopenia is very rare and bone resorption is not clinically relevant. I am stopping it at 36-37 weeks. Table 2 - Initial treatment doses (dose banded) for pregnant patients at NUH & SFH are as follows: Early pregnancy weight Dose of subcutaneous enoxaparin for VTE treatment in pregnancy <50 kg 40mg twice a day 50-69 kg 60mg twice a day Often IVF clinics will recommend having Clexane or low dose aspirin as well as the benefits far outweigh the risks in many cases. Enoxaparin: high prophylaxis (subcut) • 50−130 kg 80 mg daily Either of: • > 1 laboratory thrombophilia • Antiphospholipid syndrome Therapeutic anticoagulation 6 weeks or longer Therapeutic anticoagulation • ORAntithrombin deficiency Therapeutic anticoagulation 6 weeks Any of: • Homozygous o Factor V Leiden o Prothrombin mutation Clexane is a class of drug called a low-molecular-weight heparin (LMWH). If antithrombotic therapy is prescribed during pregnancy prior to a diagnosis of COVID-19, this therapy should be continued (AIII). followed by. (I was diagnosed with a Sub-clavian Vein thrombosis 2008, Thrombophillya test boarder line) I was not told then that it would affect any future pregnancies so this is a shock!! Continuous IV infusion for a … Clexane is certainly needed when there’s a high risk the blood might get too thick. IV loading dose of 5,000 IU.