I was told that normal levels are 3.8 to 11.4. Elevated Tryptase level and not it's dcrease is important in diagnosis of mast cell activation disorders .Therefore decreased level of tryptase has no clinical importance. With anaphylaxis, tryptase levels typically peak about 1 to 2 hours after symptoms begin. It is more tricky to diagnose MCAS, because it is a disease of exclusion (you need to first rule out other possible explanations for your symptoms). Likewise, SSM is partially defined by a very high serum tryptase level exceeding 200 ng/mL, and in many of these cases, progression dose not occur for many years. I finally just got my tryptase results from my blood work back in December. Increases in serum mast cell tryptase and in urine levels of N-methylhistamine, 11B -Prostaglandin F2α (11B-PGF2α) and/or Leukotriene E4 (LTE4) are the only useful tests in diagnosis of MCAS. Tryptase has potent biologic activities that may contribute to ⦠Although a serum tryptase level >20 ng/mL serves as a minor diagnostic criterion for SM, a minority of patients with histopathologically proven SM can exhibit values lower than this threshold. 6 Levels of serum tryptase are affected by many factors, those include age, obesity, smoking, or ⦠Again, a persistently elevated tryptase may be a reliable marker of an increased *number* of mast cells in a person, and a clear, brief spike in the tryptase level over some lower, stable baseline level of tryptase probably represents a brief flare of mast cell activation, but such a spike it is not a *reliable* marker of mast cell activation. Cite. Levels of Tryptase in Serum: In the general population baseline serum tryptase level is 5.1 ng/mL with a range from <1 to 31 ng/mL. In healthy twins tryptase level is related to genetics. This was a baseline reading. To the scientistsâ surprise, all those with high blood levels of tryptase also had duplications of the alpha tryptase gene. It should not be drawn immediately after a major allergic reaction, as that can lead to an elevated tryptase for a different reason. If a sample is drawn too early or late, results may be normal. I spent so much time researching about high tryptase levels and didn't spend any time on low ones. Total serum mast cell tryptase should be drawn between 30 minutes and two hours after the start of an episode, with baseline level obtained many days later. Many people with the duplicate gene reported experiencing symptoms similar to those seen in the original group of severely affected families, including irritable bowel syndrome, skin flushing and itching. A serum level greater than 10 ng/ml is suggestive of alpha tryptasemia, while a level lower than 8ng/ml makes this diagnosis far less likely. Tryptase is a type of protein and the elevations are due to multiple copies of an Alpha Tryptase gene. The presence of systemic mast cell degranulation is evidenced by an increase in serum/plasma tryptase. If a histamine test is also performed, it can be compared to the tryptase levels. Tryptase, being a large protein has a much longer serum half-life (3 hours) than the histamine (20 min) that is released at the same time. My reading came back as 2.1. Indication: Suspected analphylactic reaction; Diagnosis of mastocytosis. Previous studies had shown that approximately 4-6% of the general public has high tryptase levels, however not all of those people experienced these ⦠The majority of people with MCAS have a lower, or even normal tryptase level, but their symptoms (and the treatment) are similar to mastocytosis. 3. In adult patients with MIS or hymenoptera allergy, a serum tryptase level >20 ng/mL is suggestive of the presence of SM. Histamine concentrations peak within several minutes of the onset of anaphylaxis and fall within about an hour. Contrasting the smoldering state, most patients with typical ISM have lower serum tryptase levels, although enzyme levels can vary widely among patients according to the MC burden. Tryptase levels are elevated in the bronchoalveolar lavage (BAL)5 ï¬uid from atopic asthmatics compared with nonasthmatic controls at baseline (6, 7) and are signiï¬cantly increased shortly after Ag challenge in patients with allergic asthma (8). Interpretation: